Hepatotoxicity following vincristine therapy

Coma associated with vincristine therapy.

Three cases of coma after vincristine therapy are described. One patient had hyponatraemia and other features of inappropriate secretion of antidiuretic hormone. The effects were temporary, and full recovery occurred in all three patients.

Chemoprotective effect of Fumaria parviflora L. extract against vincristine induced hepatotoxicity in male rats

Background: Hepatoprotective effects of Fumaria parviflora have been approved in pharmaceutical and chemical toxicity models. Given the importance of the vincristine- induced hepatotoxicity during chemotherapy, the aim of this study was to investigate the potential hepatoprotective effects of F. parviflora extract on vincristine induced toxicity in adult male rats. Materials and methods: In thi...

Hepatotoxicity of molecular targeted therapy

A constant increase in occurrence of neoplasms is observed; hence new methods of therapy are being intensively researched. One of the methods of antineoplastic treatment is molecular targeted therapy, which aims to influence individual processes occurring in cells. Using this type of medications is associated with unwanted effects resulting from the treatment. Liver damage is a major adverse ef...

Bilateral vocal cord paralysis following treatment with vincristine.

The neurotoxicity of the vincristine is well known, however, cranial neuropathy is not widely recognized. We describe a child with acute lymphoblastic leukemia who developed vincristine-induced bilateral vocal cord paralysis. Vocal cord paralysis resolved spontaneously upon withdrawal of the vincristine. Vinca-alkaloid-induced vocal cord paralysis is a potentially dangerous but reversible condi...

Hematopoiesis and serum iron changes following vincristine sulfate.